GSK778

GSK778 is a bromodomain 1 (BD1) inhibitor. It selectively inhibits BD1 in bromodomain-containing protein 2 (BRD2), BRD3, BRD4, and bromodomain testis-specific protein (BRDT, IC50s = 79.43, 39.81, 39.81, and 158.49 nM, respectively, in time-resolved FRET assays) over BD2 in BRD2, BRD3, BRD4, and BRDT (IC50s = 3,162, 1,000, 6,309, and >10,000 nM, respectively, in time-resolved FRET assays). GSK778 inhibits LPS-induced increases in IL-6 and chemokine (C-C motif) ligand 2 (CCL2) secretion from primary human peripheral blood mononuclear cells (PBMCs, IC50s = 63.12 and 50.12 nM, respectively). It inhibits the proliferation of MV4-11 acute myeloid leukemia cells (IC50 = 200 nM).Formal Name: 7-(3,5-dimethyl-4-isoxazolyl)-2-(methoxymethyl)-1-[(1R)-1-phenylethyl]-8-[(3S)-3-pyrrolidinylmethoxy]-1H-imidazo[4,5-c]quinoline. CAS Number: 2451862-42-1. Synonyms: iBET-BD1, iBET-Bromodomain 1. Molecular Formula: C30H33N5O3. Formula Weight: 511.6. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Soluble: >10 mg/ml. SMILES: C[C@H](C1=CC=CC=C1)N2C(COC)=NC(C=NC3=C4)=C2C3=CC(OC[C@H]5CCNC5)=C4C6=C(ON=C6C)C. InChi Code: InChI=1S/C30H33N5O3/c1-18-29(20(3)38-34-18)24-12-25-23(13-27(24)37-16-21-10-11-31-14-21)30-26(15-32-25)33-28(17-36-4)35(30)19(2)22-8-6-5-7-9-22/h5-9,12-13,15,19,21,31H,10-11,14,16-17H2,1-4H3/t19-,21+/m1/s1. InChi Key: ZORLJXWXFABTPZ-CTNGQTDRSA-N.