47 products were found matching "K11721"!

RVX-297 is an inhibitor of the bromodomain and extra-terminal domain (BET) family protein bromodomain 2 (BD2). It inhibits BD2 in bromodomain-containing protein 2 (BRD2), BRD3, and BRD4, (IC50s = 0.08, 0.05, and 0.02 µM, respectively) and is selective for BD2 over BD1 (IC50s = 3.76, 2.34, and 1.16 µM for BRD2, BRD3,...

Protein function: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets. Regulates transcription of the CCND1...

(+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains. (+)-JQ1 has been shown to inhibit BRD4 (BD1) with a Kd of 50 nM, and BRD4 (BD2) with a Kd of 90 nM.

Protein function: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets. Regulates transcription of the CCND1...

iBET-BD2 is an inhibitor of the bromodomain and extra-terminal domain (BET) family protein bromodomain 2 (BD2). It inhibits BD2 in bromodomain-containing protein 2 (BRD2), BRD3, BRD4, and BRDT (IC50s = 264, 98, 49, and 214 nM, respectively) and is selective for BD2 over BD1 (IC50s = 10.96, 36.31, 70.55, and >50.11...

Human Bromodomain containing 3, also known as BRD3 or RING3L, amino-acids 29-145 (GenBank Accession No. NM_007371) with N-terminal HIS tag, MW = 14.9 kDa, expressed in an E. coli expression system.

Human Bromodomain containing 3, also known as BRD3 or RING3L, amino-acids 306-417 (GenBank Accession No. NM_007371) with N-terminal HIS tag, MW = 14.1 kDa, expressed in an E. coli expression system.

Human Bromodomain containing 3, also known as BRD3 or RING3L, amino-acids 29-145 (GenBank Accession No. NM_007371) with N-terminal GST tag, MW = 40.7 kDa, expressed in an E. coli expression system.

Human Bromodomain containing 3, also known as BRD3 or RING3L, amino-acids 306-417 (GenBank Accession No. NM_007371) with N-terminal GST tag, MW = 40 kDa, expressed in an E. coli expression system

Human Bromodomain containing 3, also known as BRD3 or RING3L, amino-acids 29 - 417 (GenBank Accession No. NM_007371) with N-terminal HIS tag, MW = 44.2 kDa, expressed in an E. coli expression system.

Human Bromodomain containing 3, also known as BRD3 or RING3L, amino-acids 29 - 417 (GenBank Accession No. NM_007371) with N-terminal GST tag, MW = 70 kDa, expressed in an E. coli expression system.

The BRD3 (BD1) Inhibitor Screening Assay Kit is designed to measure the inhibition of BRD3 bromodomain 1 (BD1) binding to its substrate. The BRD3 (BD1) Inhibitor Screening Assay Kit comes in a convenient AlphaLISA® format, with biotinylated histone peptide substrate, assay buffer, detection buffer and purified BRD3...