GSK2983559

GSK2983559 is a receptor-interacting protein kinase 2 (RIPK2) inhibitor. It inhibits RIPK2 by 65% in a kinase assay when used at a concentration of 10 µM. GSK2983559 (10 µM) also inhibits VEGFR3 by greater than 90%, as well as 14 additional kinases by 60 to 89% in a panel of 344 kinases. In vivo, GSK2983559 (7.5 and 145 mg/kg twice per day) reduces colonic damage in a mouse model of TNBS-induced colitis. GSK2983559 is also a prodrug that is cleaved to an active metabolite in the gastrointestinal tract that inhibits RIPK2 more potently than GSK2983559.Formal Name: 2-[[4-(5-benzothiazolylamino)-6-[(1,1-dimethylethyl)sulfonyl]-7-quinazolinyl]oxy]-ethanol, 1-(dihydrogen phosphate). CAS Number: 1579965-12-0. Molecular Formula: C21H23N4O7PS2. Formula Weight: 538.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: slightly soluble, DMSO: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 218, 245, 344 nm. SMILES: O=P(O)(OCCOC1=CC2=NC=NC(NC3=CC4=C(SC=N4)C=C3)=C2C=C1S(=O)(C(C)(C)C)=O)O. InChi Code: InChI=1S/C21H23N4O7PS2/c1-21(2,3)35(29,30)19-9-14-15(10-17(19)31-6-7-32-33(26,27)28)22-11-23-20(14)25-13-4-5-18-16(8-13)24-12-34-18/h4-5,8-12H,6-7H2,1-3H3,(H,22,23,25)(H2,26,27,28). InChi Key: MJLYDVMFNHZMLV-UHFFFAOYSA-N.