36 products were found matching "K08846"!

GSK583 is a selective inhibitor of RIP-like interacting CLARP kinase (RICK also known as RIP2 kinase, IC50 = 5 nM). RIP2 Kinase is a central component of the innate immune system and enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to the production of...

WEHI-345 is an inhibitor of receptor-interacting protein kinase 2 (RIPK2, IC50 = 130 nM in a kinase assay using human recombinant RIPK2). It is selective for RIPK2 over RIPK1, 4, and 5 (Kds = 46, >10,000, >10,000, and >10,000 nM, respectively) and a panel of 95 kinases at a concentration of 1 µM. WEHI-345 reduces...

GSK2983559 is a receptor-interacting protein kinase 2 (RIPK2) inhibitor. It inhibits RIPK2 by 65% in a kinase assay when used at a concentration of 10 µM. GSK2983559 (10 µM) also inhibits VEGFR3 by greater than 90%, as well as 14 additional kinases by 60 to 89% in a panel of 344 kinases. In vivo, GSK2983559 (7.5 and...

Protein function: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the...

Protein function: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the...

Recombinant human RIPK2 (GenBank Accession No. NM_003821), (a.a. 1-299) with N-terminal Gst-tag, MW=59 kDa, expressed in an baculovirus infected Sf9 cell expression system.

Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. The DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis. A novel CARD-containing serine/threonine kinase that regulates apoptosis was identified and...

Anti-RICK Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with RICK from other sources has not been determined. Protein function: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon...

Anti-RICK Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with RICK from other sources has not been determined. Protein function: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Receptor-interacting serine/threonine-protein kinase 2, also known as CARD3, CARDIAK, RICK, and RIP2, is an enzyme that in humans is encoded by the RIPK2 gene. It has 540-amino acid protein in length. Northern blot analysis revealed that RIPK2 is expressed in...

In 1X PBS, pH 7.4, with 0.09% sodium azide. RIPK2 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a...