GSK1482160

A P2X7 receptor antagonist (IC50 = 3.2 nM for the human receptor), inhibits LPS- and BzATP-induced increases in ROS levels in THP-1 macrophages at 1 µM, decreases the accumulation of misfolded tau aggregates in the brain and improves learning and memory in the Y-maze and contextual fear conditioning tests in human P301S tau transgenic mice at 20 mg/kg twice per day, reverses mechanical allodynia in a rat model of chronic constriction injury-induced allodynia at 20 mg/kg. Formulation: A solid. InChI: InChI=1S/C14H14ClF3N2O2/c1-20-10(5-6-11(20)21)13(22)19-7-8-3-2-4-9(12(8)15)14(16,17)18/h2-4,10H,5-7H2,1H3,(H,19,22)/t10-/m0/s1. InChIKey: BJEMSIVBBUBXMZ-JTQLQIEISA-N. SMILES: O=C([C@@H]1CCC(N1C)=O)NCC2=C(C(C(F)(F)F)=CC=C2)Cl