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Item number: TGM-T61025-100mg

Description: GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so GSK-1482160 has the potential to study inflammatory diseases. GSK-1482160 shows...

CAS	1001389-72-5
MW:	334.72 D

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GSK1482160

Item number: Cay41980-10

A P2X7 receptor antagonist (IC50 = 3.2 nM for the human receptor), inhibits LPS- and BzATP-induced increases in ROS levels in THP-1 macrophages at 1 µM, decreases the accumulation of misfolded tau aggregates in the brain and improves learning and memory in the Y-maze and contextual fear conditioning tests in human...

Keywords:	(2S)-N-[[2-chloro-3-(trifluoromethyl)phenyl]methyl]-1-methyl-5-oxo-2-pyrrolidinecarboxamide
Application:	P2X7 receptor antagonist
CAS	1001389-72-5
MW:	334.72 D

From 120.00€ *

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