GR87389

An NK2 receptor antagonist, inhibits NKA binding in rat hippocampal, urinary bladder, and duodenal membranes (Kis = 4, 5.2, and 14 nM, respectively), inhibits GR64349-induced contraction of isolated human detrusor muscle at 30, 100, and 300 nM. SMILES: O=C(N1[C@H](CCC1)C(N2[C@@H](CCC2)C(N[C@H](C(N)=O)CCCC)=O)=O)[C@H](CC3=CC=CC=C3)NC([C@H](NC([C@H](C)NC([C@H](C)NC(OC(C)(C)C)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O. InChi Code: InChI=1S/C47H65N9O9/c1-7-8-19-34(39(48)57)52-43(61)37-21-14-23-55(37)45(63)38-22-15-24-56(38)44(62)36(25-30-16-10-9-11-17-30)54-42(60)35(26-31-27-49-33-20-13-12-18-32(31)33)53-41(59)28(2)50-40(58)29(3)51-46(64)65-47(4,5)6/h9-13,16-18,20,27-29,34-38,49H,7-8,14-15,19,21-26H2,1-6H3,(H2,48,57)(H,50,58)(H,51,64)(H,52,61)(H,53,59)(H,54,60)/t28-,29-,34-,35+,36-,37-,38+/m0/s1. InChi Key: TULKQVVKMIIQFE-DWZVVYGRSA-N