39 products were found matching "K04223"!

An NK2 receptor antagonist, inhibits NKA binding in rat hippocampal, urinary bladder, and duodenal membranes (Kis = 4, 5.2, and 14 nM, respectively), inhibits GR64349-induced contraction of isolated human detrusor muscle at 30, 100, and 300 nM. SMILES:...

GR83074 is a peptide antagonist of the neurokinin-2 (NK2) receptor. It selectively inhibits neurokinin A-induced contractions in rat colon muscularis mucosae, which express NK2 receptors, over substance P-induced contractions in guinea pig ileum longitudinal smooth muscle strips, which express NK1 receptors (pKbs =...

Recombinant CHO-K1 cells stably overexpress human tachykinin receptor 2 (NK2) on the surface and contain high levels of G protein Galphaq and Galphas to couple with the receptor in downstream signaling pathways.

A peptide agonist of the NK2 receptor, selectively induces contractions in isolated rat colon muscularis mucosae, which endogenously express NK2 receptors, over isolated guinea pig ileum longitudinal smooth muscle and everted rat portal vein, which endogenously express NK1 and NK3 receptors, respectively (EC50s =...

A peptide antagonist of the NK2B receptor (pA2 = 7.63), selective for the NK2B receptor over NK1, NK2A, and NK3 receptors (pA2s = <5, 5.41, and <5, respectively), intracerebroventricular administration inhibits NKA- but not substance P-induced increases in mean arterial blood pressure, heart rate, face washing, and...

MEN10207 is a peptide neurokinin-2 (NK2) receptor antagonist. It inhibits contractions induced by neurokinin A (NKA) in endothelium-deprived isolated rabbit pulmonary artery (pA2 = 7.89), which is endogenously enriched in NK2 receptors. It is selective for NK2 receptors in isolated rabbit pulmonary artery over NK2...

GR73632 is a peptide neurokinin-1 (NK1) receptor agonist. It potentiates electrically induced contractions in isolated guinea pig vas deferens (EC50 = 2 nM). Intradermal administration of GR73632 (30 nmol/animal) increases scratching behavior in gerbils. It induces foot tapping behavior in gerbils when...

[Lys5,MeLeu9,Nle10]-Neurokinin A (4-10) is a neurokinin-2 (NK2) receptor agonist and derivative of neurokinin A (Cay-24221). It binds to NK2 receptors in isolated human colon circular muscle membranes in a radioligand binding assay (IC50 = 0. nM). [Lys5,MeLeu9,Nle10]-Neurokinin A (4-10) induces contraction of...

An NK2 (tachykinin receptor 2) antagonist.

ELISA Type: CLIA. Sensitivity: 37.5 pg/mL. Range: 62.5--4000 pg/mL. Protein function: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to...