GR46611

A 5-HT1D agonist, induces cAMP accumulation in CHO cells expressing the human receptor at 10 µM, binds to 5-HT1A and 5-HT1B receptors (Kis = 1.3 and 0.2 nM, respectively)induces hypothermia and decreases hypothalamus and prefrontal cortex levels of 5-HIAA in guinea pigs at 50 µmol/kg, potentiates buspirone- or 8-hydroxy DPAT-induced increases in locomotor activity in guinea pigs at 2.5 mg/kg, impairs memory consolidation in an autoshaping learning task in mice when administered after training at 10 mg/kg. Formulation: A solid. InChI: InChI=1S/C23H27N3O2/c1-26(2)13-12-19-16-24-22-10-6-17(14-21(19)22)7-11-23(27)25-15-18-4-8-20(28-3)9-5-18/h4-11,14,16,24H,12-13,15H2,1-3H3,(H,25,27). InChIKey: LBVZWEWTNUDWNS-UHFFFAOYSA-N. SMILES: O=C(C=CC1=CC=C2NC=C(CCN(C)C)C2=C1)NCC3=CC=C(OC)C=C3