GNF-362

GNF-362 is an inositol triphosphate 3 kinase (ITPK) inhibitor (IC50s = 20, 9, and 19 nM for ITPKA, ITPKB, and ITPKC, respectively). It induces calcium influx in isolated mouse splenocytes (EC50 = 12 nM). In vivo, GNF-362 (10 and 25 mg/kg) reduces the number of thymic CD4+ T cells in mice. It also reduces inflammatory cell infiltration, joint erosion, and proteoglycan loss, in a rat model of antigen-induced arthritis when administered at a dose of 20 mg/kg.Formal Name: 4-[4-[[(3R)-3-methyl-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl]methyl]-1H-pyrazol-3-yl]-benzonitrile. CAS Number: 1003019-41-7. Molecular Formula: C22H21F3N6. Formula Weight: 426.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: N#CC(C=C1)=CC=C1C2=NNC=C2CN3C[C@H](N(C4=CC=C(C=N4)C(F)(F)F)CC3)C. InChi Code: InChI=1S/C22H21F3N6/c1-15-13-30(8-9-31(15)20-7-6-19(12-27-20)22(23,24)25)14-18-11-28-29-21(18)17-4-2-16(10-26)3-5-17/h2-7,11-12,15H,8-9,13-14H2,1H3,(H,28,29)/t15-/m1/s1. InChi Key: VNTCGXMLDSKOKN-OAHLLOKOSA-N.