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Item number: Cay35866-1

GNF-362 is an inositol triphosphate 3 kinase (ITPK) inhibitor (IC50s = 20, 9, and 19 nM for ITPKA, ITPKB, and ITPKC, respectively). It induces calcium influx in isolated mouse splenocytes (EC50 = 12 nM). In vivo, GNF-362 (10 and 25 mg/kg) reduces the number of thymic CD4+ T cells in mice. It also reduces...

Keywords:	4-[4-[[(3R)-3-methyl-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl]methyl]-1H-pyrazol-3-yl]-benzonitrile
Application:	ITPK1 inhibitor
CAS	1003019-41-7
MW:	426.4 D

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