GLPG0492

GLPG0492 is a selective androgen receptor modulator (SARM). It activates the androgen receptor in a transactivation assay (EC50 = 12 nM in HeLa cells expressing the human receptor). GLPG0492 (10 mg/kg per day) increases levator ani muscle weight, a marker of anabolic activity, but has no effect on ventral prostate weight, a marker of androgenic activity, in castrated rats. It increases twitch tension in isolated diaphragm strips, as well as increases the total distance run in a treadmill test and decreases gastrocnemius muscle fibrosis in the exercised-mdx mouse model of muscular dystrophy when administered at a dose of 30 mg/kg. GLPG0492 also reverses immobilization-induced muscle atrophy in a mouse model of hindlimb immobilization.Formal Name: 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)-benzonitrile. CAS Number: 1215085-92-9. Molecular Formula: C19H14F3N3O3. Formula Weight: 389.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Ethanol: slightly soluble. SMILES: O=C([C@@](CO)(C1=CC=CC=C1)N2C)N(C3=CC(C(F)(F)F)=C(C#N)C=C3)C2=O. InChi Code: InChI=1S/C19H14F3N3O3/c1-24-17(28)25(14-8-7-12(10-23)15(9-14)19(20,21)22)16(27)18(24,11-26)13-5-3-2-4-6-13/h2-9,26H,11H2,1H3/t18-/m1/s1. InChi Key: VAJGULUVTFDTAS-GOSISDBHSA-N.