Glecirasib

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Item number	Size	Manual	Delivery time	Price
Cay45041-1	1 mg	-	6 - 10 business days*	147.00€
Cay45041-5	5 mg	-	6 - 10 business days*	405.00€
Cay45041-10	10 mg	-	6 - 10 business days*	588.00€

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A covalent K-RasG12C inhibitor (IC50 = 1.6 nM), inhibits ERK phosphorylation in... more

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Product information "Glecirasib"

A covalent K-RasG12C inhibitor (IC50 = 1.6 nM), inhibits ERK phosphorylation in K-RasG12C-expressing NCI H358 non-small cell lung cancer (NSCLC) cells (IC50 = 7.3 nM) and reduces their viability (IC50 = 23 nM), inhibits tumor growth in an NCI H1373 NSCLC mouse xenograft model at 10 mg/kg. SMILES: FC(C(C1=NC(N2C3=C(C=CN=C3C(C)C)C)=C(C=C1Cl)C(N4CCN(CC4)C(C=C)=O)=C(C#N)C2=O)=C(N)C(F)=C5F)=C5F. InChi Code: InChI=1S/C31H26ClF4N7O2/c1-5-19(44)41-8-10-42(11-9-41)29-16-12-18(32)27(20-21(33)22(34)23(35)24(36)25(20)38)40-30(16)43(31(45)17(29)13-37)28-15(4)6-7-39-26(28)14(2)3/h5-7,12,14H,1,8-11,38H2,2-4H3. InChi Key: QRRJEUIQLZNPIO-UHFFFAOYSA-N

Keywords:	7-(2-amino-3,4,5,6-tetrafluorophenyl)-6-chloro-1,2-dihydro-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-2-oxo-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-1,8-naphthyridine-3-carbonitrile
Supplier:	Cayman Chemical
Supplier-Nr:	45041

Properties

Application:	Covalent K-RasG12C inhibitor
MW:	640.04 D
Formula:	C31H26ClF4N7O2
Purity:	>98%
Format:	Solid

Database Information

CAS :	2657613-87-9\| Matching products
KEGG ID :	K07827 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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