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GBR 12935 is an inhibitor of dopamine uptake that binds to the dopamine transporter (Kd = 27.2 nM). It is selective for the dopamine transporter over the serotonin and norepinephrine transporters (Kds = 940 and 310 nM, respectively). In mice, it increases locomotor activity, but not stereotypic behavior, when administered at a dose of 10 mg/kg but induces gnawing at levels similar to other indirect dopamine agonists with an ED50 value of 17.1 mg/kg.Formal Name: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine, dihydrochloride. CAS Number: 67469-81-2. Molecular Formula: C28H34N2O . 2HCl. Formula Weight: 487.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml. SMILES: C1(C(OCCN2CCN(CCCC3=CC=CC=C3)CC2)C4=CC=CC=C4)=CC=CC=C1.Cl.Cl. InChi Code: InChI=1S/C28H34N2O.2ClH/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27,,/h1-9,11-12,14-17,28H,10,13,18-24H2,2*1H. InChi Key: NQWRSILGEXNJIT-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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