G10

G10 is an indirect activator of stimulator of interferon genes (STING) signaling. It induces transcription of genes dependent on IRF3 and IFN, which are activated by STING, but has no effect on non-STING activated NF-kappaB-dependent transcription of IL-8, IL-1beta, or MIP-1alpha in human fibroblasts. However, G10 does increase expression of NF-kappaB-dependent genes in human peripheral blood mononuclear cells (PBMCs) and human umbilical microvascular endothelial cells (HUMECs). In vitro, it prevents replication of the chikungunya and Venezuelan equine encephalitis alphaviruses (IC90s = 8.01 and 24.57 µM, respectively). G10 (100 µM) increases phosphorylation of IRF3, which is lost in cells lacking STING.Formal Name: 4-[(2-chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide. CAS Number: 702662-50-8. Synonyms: STING Agonist-1. Molecular Formula: C21H16ClFN2O3S. Formula Weight: 430.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 253, 292 nm. SMILES: O=C1CSC2=C(C=C(C(NCC3=CC=CO3)=O)C=C2)N1CC4=C(Cl)C=CC=C4F. InChi Code: InChI=1S/C21H16ClFN2O3S/c22-16-4-1-5-17(23)15(16)11-25-18-9-13(6-7-19(18)29-12-20(25)26)21(27)24-10-14-3-2-8-28-14/h1-9H,10-12H2,(H,24,27). InChi Key: NAGKYJATVFXZKN-UHFFFAOYSA-N.