FT709

FT709 is an inhibitor of ubiquitin-specific protease 9X (USP9X, IC50 = 82 nM). It is selective for USP9X over a panel of 20 deubiquitinases (IC50s = >25 µM for all). FT709 (10 µM) decreases the levels of the USP9X substrate centrosomal protein of 55 kDa (CEP55), as well as zinc-finger protein 598 (ZNF598), makorin 1 (MKRN1), and MKRN2, which are involved in the ribosomal quality control pathway, and inhibits the ribosomal stalling response to polyA tracts, a translation quality-control process, in a reporter assay using HEK293 cells.Formal Name: (2S)-1-[5-[(2,3-dihydro-1,4-dioxino[2,3-b]pyridin-7-yl)sulfonyl]-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-2-hydroxy-2-(2-methyl-4-benzoxazolyl)-ethanone. CAS Number: 2413991-74-7. Molecular Formula: C23H22N4O7S. Formula Weight: 498.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: O=[S](N1CC(CN2C([C@H](C3=C(N=C4C)C(O4)=CC=C3)O)=O)=C(C2)C1)(C5=CN=C6C(OCCO6)=C5)=O. InChi Code: InChI=1S/C23H22N4O7S/c1-13-25-20-17(3-2-4-18(20)34-13)21(28)23(29)26-9-14-11-27(12-15(14)10-26)35(30,31)16-7-19-22(24-8-16)33-6-5-32-19/h2-4,7-8,21,28H,5-6,9-12H2,1H3/t21-/m0/s1. InChi Key: SCFWBZTVFCUBIZ-NRFANRHFSA-N.