FT113

FT113 is an inhibitor of fatty acid synthase (FASN, IC50 = 213 nM). It inhibits the proliferation of PC3 human prostate cancer and MV4-11 human acute myeloid leukemia cells (IC50s = 47 and 26 nM, respectively) and inhibits FASN activity in a 14C-acetate incorporation assay using BT474 human breast cancer cells (IC50 = 90 nM). FT113 (25 and 50 mg/kg) reduces tumor growth and increases intratumoral levels of the FASN substrate malonyl-CoA in an MV4-11 mouse xenograft model. It also inhibits infection of HEK293T cells expressing human angiotensin-converting enzyme 2 (HEK293T-hACE2 cells) with an infectious-clone-derived mNeonGreen severe acute respiratory syndrome coronavirus 2 reporter virus (SARS-CoV-2-mNG) with an EC50 value of 17 nM.Formal Name: [4-[4-(6-fluoro-2-benzoxazolyl)benzoyl]-1-piperazinyl](1-hydroxycyclopropyl)-methanone. CAS Number: 1630808-89-7. Molecular Formula: C22H20FN3O4. Formula Weight: 409.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: Soluble, Methanol: Soluble. SMILES: O=C(N1CCN(CC1)C(C2(CC2)O)=O)C3=CC=C(C4=NC5=C(O4)C=C(F)C=C5)C=C3. InChi Code: InChI=1S/C22H20FN3O4/c23-16-5-6-17-18(13-16)30-19(24-17)14-1-3-15(4-2-14)20(27)25-9-11-26(12-10-25)21(28)22(29)7-8-22/h1-6,13,29H,7-12H2. InChi Key: DSTWHRGOCUOKDE-UHFFFAOYSA-N.