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Foretinib is a broad-spectrum tyrosine kinase (TK) inhibitor that targets members of the HGF and VEGF receptor TK families, as well as KIT, Flt-3, PDGFRbeta, and Tie-2, at nanomolar concentrations. It blocks HGF-induced Met phosphorylation and VEGF-induced ERK phosphorylation, preventing HGF-induced responses in tumor cells and HGV/VEGF-induced responses in endothelial cells. Foretinib is functional in vivo, reducing tumor burden in an experimental model of lung metastasis.Formal Name: N-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide. CAS Number: 849217-64-7. Synonyms: GSK1363089, XL880. Molecular Formula: C34H34F2N4O6. Formula Weight: 632.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 16 mg/ml, Ethanol: 25 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 242 nm. SMILES: COC(C=C(C(OC1=CC=C(NC(C2(CC2)C(NC3=CC=C(F)C=C3)=O)=O)C=C1F)=CC=N4)C4=C5)=C5OCCCN6CCOCC6. InChi Code: InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42). InChi Key: CXQHYVUVSFXTMY-UHFFFAOYSA-N.
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