FIN56

FIN56 is an inducer of ferroptosis and a derivative of CIL56 (Cay-19287). It selectively induces ferroptosis in BJ cells overexpressing oncogenic HRASG12V via acetyl-CoA carboxylase-dependent reduction in expression of GPX4 protein. This effect is reversed by the ferroptosis inhibitors deferoxamine (Cay-14595) and alpha-tocopherol as well as overexpression of the fusion protein GFP-GPX4. FIN56 also binds to and activates squalene synthase in a GPX4 degradation-independent manner.Formal Name: N2,N7-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide. CAS Number: 1083162-61-1. Molecular Formula: C25H31N3O5S2. Formula Weight: 517.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml. lambdamax: 223, 267, 305 nm. SMILES: O/N=C1C2=C(C=CC(S(NC3CCCCC3)(=O)=O)=C2)C4=C/1C=C(S(NC5CCCCC5)(=O)=O)C=C4. InChi Code: InChI=1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,27-29H,1-10H2. InChi Key: JLCFMMIWBSZOIS-UHFFFAOYSA-N.