FG-7142

FG-7142 is a benzodiazepine receptor ligand with anxiogenic and proconvulsant properties. It increases benzodiazepine receptor ligand binding and GABA-dependent chloride uptake in primary chick cerebral cortical neurons when used at a concentration of 1 µM. FG-7142 (5 mg/kg) decreases pinning of the other animal and increases avoiding behavior in rats, an effect that can be prevented by the benzodiazepine receptor antagonist Ro 15-1788 (flumazenil, Cay-14252). It reduces the infused pentylenetetrazol (PTZ, Cay-18682) seizure threshold and induces generalized seizures in mice when administered at doses of 10 and 40 mg/kg, respectively. FG-7142 (3.75, 7.5, and 15 mg/kg, i.p.) also decreases food and water intake, eating rate, and time spent in the open arms of the elevated plus maze in female rats.Formal Name: N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide. CAS Number: 78538-74-6. Synonyms: ZK 39106. Molecular Formula: C13H11N3O. Formula Weight: 225.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 1 mg/ml. lambdamax: 217, 235, 271 nm. SMILES: O=C(NC)C1=NC=C2C(C3=C(C=CC=C3)N2)=C1. InChi Code: InChI=1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17). InChi Key: QMCOPDWHWYSJSA-UHFFFAOYSA-N.