53 products were found matching "K05186"!

Indiplon is a pyrazolopyrimidine that acts as a high-affinity positive allosteric modulator of the GABAA receptor, potentiating GABA-activated chloride currents in a dose-dependent and reversible manner. Indiplon is selective for alpha1 subunits (EC50 = 2.6 nM) as compared with alpha2, alpha3, or alpha5 (EC50 = 24,...

Picrotoxin is a natural plant-derived poison that acts as a selective GABAA receptor antagonist. It is functional in vivo and is used to study the role of GABAA receptors in the central nervous system as well in the periphery. Picrotoxin induces seizures in adult and immature animals and is used to study...

Anti-GABA(A) Receptor gamma 2 Antibody is directed against rat GABA(A) Receptor gamma 2. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Reactivity is expected fromthe following species based on 100% sequence homology: bovine chicken, canine, human, mouse non-human...

4'-chloro Deschloroalprazolam (Cay-36057) is an analytical reference standard categorized as a benzodiazepine. This product is intended for research and forensic applications.Formal Name: 6-(4-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine. CAS Number: 92262-72-1. Molecular Formula: C17H13ClN4....

Protein function: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital, these are bound...

Protein function: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital, these are bound...

Anti-GABA(A) Receptor gamma 2 Antibody is directed against rat GABA(A) Receptor gamma 2. The antibody was prepared from monospecific neat serum. Expect reactivity with the following species based on 100% sequence homology: bovine, chicken, human, mouse, non-human primates and zebra fish. Protein function: GABA, the...

Anti-GABA(A) Receptor gamma 2 pS327 Antibody is directed against rat phosphorylated GABA(A) Receptor gamma 2. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Immunolabeling of the GABAA band is completely blocked by ?-phosphatase treatment. This antibody is directed...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Gamma-aminobutyric acid (GABA) A receptor, gamma 2 Protein function: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions...

Protein function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [The UniProt Consortium]

GABAA receptors are ligand-gated chloride channels that mediate the effects of the inhibitory neurotransmitter GABA in the CNS. They are postsynaptic heteropentameric receptors that contain protein subunits from the following isoforms: alpha1-6, beta1-4, gamma1-3, delta, epsilon, pi, theta, and rho1-3, arranged...

FG-7142 is a benzodiazepine receptor ligand with anxiogenic and proconvulsant properties. It increases benzodiazepine receptor ligand binding and GABA-dependent chloride uptake in primary chick cerebral cortical neurons when used at a concentration of 1 µM. FG-7142 (5 mg/kg) decreases pinning of the other animal and...