Fesoterodine (fumarate)

Fesoterodine is an antagonist of muscarinic acetylcholine receptors (Kis = 15.8, 11.2, 12.6, 22.4, and 25.1 nM for human M1-5, respectively). In vivo, fesoterodine (0.01 mg/kg, i.v.) reduces micturition pressure and increases bladder capacity and intercontraction interval (ICI) in conscious female rats. Fesoterodine also reduces intermicturition pressure and prevents bladder overactivity in a rat model of spinal cord injury-induced overactive bladder.Formal Name: 2-methyl-propanoic acid, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester, (2E)-2-butenedioate. CAS Number: 286930-03-8. Synonyms: SMP 8272, SPM 907. Molecular Formula: C26H37NO3 . C4H4O4. Formula Weight: 527.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Slightly Soluble, Water: Slightly Soluble. SMILES: O=C(C(C)C)OC1=C([C@@H](C2=CC=CC=C2)CCN(C(C)C)C(C)C)C=C(CO)C=C1.OC(/C=C/C(O)=O)=O. InChi Code: InChI=1S/C26H37NO3.C4H4O4/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6,5-3(6)1-2-4(7)8/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3,1-2H,(H,5,6)(H,7,8)/b,2-1+/t23-,/m1./s1. InChi Key: MWHXMIASLKXGBU-RNCYCKTQSA-N.