Ferutinin

Ferutinin is a plant-derived ester of a sesquiterpenic alcohol that acts as an agonist for estrogen receptor (ER) alpha (IC50 = 33.1 nM) and an agonist/antagonist for ERbeta (IC50 = 180.5 nM). It also demonstrates ionophoretic properties, increasing calcium permeability of lipid bilayer membranes, mitochondria, thymocytes, sarcoplasmic reticulum, and liposomes at a concentration range of 1-50 µM. Ferutinin is cytotoxic to MCF-7 breast and TCC bladder cancer cells as well as human foreskin HFF3 fibroblasts (IC50s = 29, 24, and 36 µg/ml in vitro after 72 hours of exposure).Formal Name: 4-hydroxy-benzoic acid, (3R,3aS,4S,8aR)-1,2,3,3a,4,5,8,8a-octahydro-3-hydroxy-6,8a-dimethyl-3-(1-methylethyl)-4-azulenyl ester. CAS Number: 41743-44-6. Molecular Formula: C22H30O4. Formula Weight: 358.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 260 nm. SMILES: OC1=CC=C(C(O[C@H]2CC(C)=CC[C@]3(C)[C@]2([H])[C@@](C(C)C)(O)CC3)=O)C=C1. InChi Code: InChI=1S/C22H30O4/c1-14(2)22(25)12-11-21(4)10-9-15(3)13-18(19(21)22)26-20(24)16-5-7-17(23)8-6-16/h5-9,14,18-19,23,25H,10-13H2,1-4H3/t18-,19+,21-,22+/m0/s1. InChi Key: CYSHNJQMYORNJI-YUVXSKOASA-N. Origin: Semi-synthetic.