Ferristatin II

Ferristatin II is an inhibitor of iron uptake. It inhibits iron uptake (IC50 = ~12 µM), as well as induces degradation of transferrin receptor protein 1 (TfR1), an effect that can be reversed by the lipid membrane disruptor nystatin, in HeLa cells. In vivo ferristatin II (0.2, 10, and 40 mg/kg) reduces serum iron levels and transferrin saturation in rats. It also suppresses traumatic brain injury-induced lipid peroxidation, neuronal apoptosis, and the number of cortical iron deposits in rats.Formal Name: 4-amino-3-[2-[4'-[2-(2,4-diaminophenyl)diazenyl][1,1'-biphenyl]-4-yl]diazenyl]-5-hydroxy-6-(2-phenyldiazenyl)-2,7-naphthalenedisulfonic acid, disodium salt. CAS Number: 1937-37-7. Synonyms: Chlorazol Black, C.I. 30235, NSC 8679. Molecular Formula: C34H25N9O7S2 . 2Na. Formula Weight: 781.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: PBS (pH 7.2): 1 mg/ml. lambdamax: 596 nm. SMILES: O=S([O-])(C1=CC2=CC(S(=O)([O-])=O)=C(C(N)=C2C(O)=C1N=NC3=CC=CC=C3)N=NC4=CC=C(C5=CC=C(N=NC6=CC=C(C=C6N)N)C=C5)C=C4)=O.[Na+].[Na+]. InChi Code: InChI=1S/C34H27N9O7S2.2Na/c35-22-10-15-27(26(36)18-22)41-38-24-11-6-19(7-12-24)20-8-13-25(14-9-20)40-42-32-28(51(45,46)47)16-21-17-29(52(48,49)50)33(34(44)30(21)31(32)37)43-39-23-4-2-1-3-5-23,,/h1-18,44H,35-37H2,(H,45,46,47)(H,48,49,50),,/q,2*+1/p-2. InChi Key: XRPLBRIHZGVJIC-UHFFFAOYSA-L.