FDW028

FDW028 is an inhibitor of fucosyltransferase 8 (FUC8). It binds to FUC8 (Kd = 5.486 µM) and inhibits core fucosylation in HCT-8 and SW480 colorectal cancer (CRC) cells. FDW028 (50 µM) induces degradation of B7-H3, also known as CD276, via chaperone-mediated autophagy (CMA) in the same cells. In vivo, FDW028 (10 and 20 mg/kg) reduces tumor volume and increases survival in an SW480 mouse xenograft model.Formal Name: 2-[[(4-ethylphenyl)methyl]amino]-5-[[(phenylmethyl)amino]methyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol. CAS Number: 2768426-49-7. Molecular Formula: C22H24N6O. Formula Weight: 388.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml. SMILES: OC1=CC(CNCC2=CC=CC=C2)=NC3=NC(NCC4=CC=C(CC)C=C4)=NN31. InChi Code: InChI=1S/C22H24N6O/c1-2-16-8-10-18(11-9-16)14-24-21-26-22-25-19(12-20(29)28(22)27-21)15-23-13-17-6-4-3-5-7-17/h3-12,23,29H,2,13-15H2,1H3,(H,24,27). InChi Key: LJEVZCFIZASGBF-UHFFFAOYSA-N.