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Item number: Cay39543-10

FDW028 is an inhibitor of fucosyltransferase 8 (FUC8). It binds to FUC8 (Kd = 5.486 µM) and inhibits core fucosylation in HCT-8 and SW480 colorectal cancer (CRC) cells. FDW028 (50 µM) induces degradation of B7-H3, also known as CD276, via chaperone-mediated autophagy (CMA) in the same cells. In vivo, FDW028 (10 and...

Keywords:	2-[[(4-ethylphenyl)methyl]amino]-5-[[(phenylmethyl)amino]methyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
Application:	FUT8 inhibitor
CAS	2768426-49-7
MW:	388.5 D

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