Fananserin

A 5-HT2 antagonist (IC50 = 0.12 nM for the rat receptor), selective for 5-HT2 over 5-HT1A, 5-HT3, alpha1-AR, dopamine D2 (IC50s = 75, 6,600, 4.3, and 390 nM for the rat receptors), and histamine H1 receptors (IC50 = 50 nM for the guinea pig receptor), an antagonist of the dopamine D4 receptor (Ki = 2.93 nM for the human receptor), inhibits the HTR induced by mescaline in mice (ED50 = 0.16 mg/kg), increases time in deep NREM sleep and decreases time in light NREM sleep in rats at 2 or 4 mg/kg, increases the time spent in the open arms of the elevated plus maze in mice at 0.25, 1, or 4 mg/kg. Formulation: A solid. InChI: InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2. InChIKey: VGIGHGMPMUCLIQ-UHFFFAOYSA-N. SMILES: O=S1(C2=CC=CC3=CC=CC(N1CCCN4CCN(CC4)C5=CC=C(C=C5)F)=C32)=O