EZM0414
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
EZM0414 is an inhibitor of SET domain-containing protein 2 (SETD2, IC50 = 18 nM). It inhibits the... more
Product information "EZM0414"
EZM0414 is an inhibitor of SET domain-containing protein 2 (SETD2, IC50 = 18 nM). It inhibits the proliferation of A549 non-small cell lung cancer (NSCLC) cells (EC50 = 57 nM). EZM0414 (15 and 30 mg/kg) decreases tumor volume in a KMS-11 multiple myeloma mouse xenograft model. It decreases cardiomyocyte levels of trimethylated lysine 36 on histone H3 (H3K36Me3) in a mouse model of heart failure with preserved ejection fraction (HFpEF) induced by a high-fat diet and L-NAME (Cay-80210). EZM0414 also reduces lung congestion and cardiac hypertrophy in the same model. InChI: InChI=1S/C22H29FN4O2/c1-14-6-7-19(23)18-13-20(25-21(14)18)22(29)24-16-4-3-5-17(12-16)27-10-8-26(9-11-27)15(2)28/h6-7,13,16-17,25H,3-5,8-12H2,1-2H3,(H,24,29)/t16-,17+/m1/s1, InChIKey: PGNLXEBQMQHFNK-SJORKVTESA-N, SMILES: FC1=C2C(NC(C(N[C@@H]3CCC[C@@H](C3)N4CCN(CC4)C(C)=O)=O)=C2)=C(C=C1)C
| Keywords: | N-[(1R,3S)-3-(4-acetyl-1-piperazinyl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 43914 |
Properties
| Application: | SETD2 inhibitor |
| MW: | 400.5 D |
| Formula: | C22H29FN4O2 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 2411748-50-8| Matching products |
| KEGG ID : | K11423 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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