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Item number: Cay43914-1

EZM0414 is an inhibitor of SET domain-containing protein 2 (SETD2, IC50 = 18 nM). It inhibits the proliferation of A549 non-small cell lung cancer (NSCLC) cells (EC50 = 57 nM). EZM0414 (15 and 30 mg/kg) decreases tumor volume in a KMS-11 multiple myeloma mouse xenograft model. It decreases cardiomyocyte levels of...

Keywords:	N-[(1R,3S)-3-(4-acetyl-1-piperazinyl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide
Application:	SETD2 inhibitor
CAS	2411748-50-8
MW:	400.5 D

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EZM0414

Item number: TGM-T9969-100mg

Description: EZM0414 is a potent and selective, orally bioavailable inhibitor of SETD2 with an IC50 of 18 nM in biochemical assays and 34 nM in cellular assays, potentially useful for researching relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma [1]. Target: Histone Methyltransferase. Smiles:...

CAS	2411748-50-8
MW:	400.49 D

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