EW-7197

EW-7197 is a potent inhibitor of activin receptor-like kinase 5 (ALK5, also known as TGF-beta receptor type 1, IC50 = 12.9 nM). It also inhibits ALK2 and ALK4 at nanomolar concentrations. EW-7197 blocks TGF-beta/Smad signaling, cell migration, invasion, and lung metastasis in mouse mammary tumor virus/c-Neu mice and 4TI orthotopic-grafted mice. It also inhibits epithelial-to-mesenchymal transition (EMT) in TGF-beta-treated breast cancer cells. EW-7197 is used to block TGF-beta signaling and EMT in animal models of cancer and fibrosis.Formal Name: N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine. CAS Number: 1352608-82-2. Synonyms: Vactosertib. Molecular Formula: C22H18FN7. Formula Weight: 399.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 229, 306 nm. SMILES: CC1=NC(C2=C(C(C=C3)=CN4C3=NC=N4)N=C(CNC5=CC=CC=C5F)N2)=CC=C1. InChi Code: InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29). InChi Key: FJCDSQATIJKQKA-UHFFFAOYSA-N.