Eticlopride (hydrochloride)

Eticlopride is a dopamine D2 and D3 receptor antagonist (Kis = 0.029 and 0.46 nM in MN9D mouse neuronal cells expressing rat D2 and human D3 receptors, respectively). It is selective for dopamine D2 and D3 receptors (IC50s = 1 and 113 nM, respectively) over dopamine D1, alpha2-adrenergic, and beta-adrenergic, histamine H1, and muscarinic receptors (IC50s = 700->100,000 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1 and 5-HT2 (IC50s = 6,200 and 830, respectively), but does bind alpha1-adrenergic receptors (alpha1-ARs, IC50 = 110 nM) in radioligand binding assays. Eticlopride (10 µg/kg) inhibits stereotyped behavior in rats induced by 7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT). It also inhibits ketamine- and cocaine-induced hypermotility in rats when administered at doses of 20 and 50 µg/kg, respectively.Formal Name: 3-chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-6-hydroxy-2-methoxy-benzamide, monohydrochloride. CAS Number: 97612-24-3. Synonyms: S-(-)-Eticlopride, (-)-Eticlopride. Molecular Formula: C17H25ClN2O3 . HCl. Formula Weight: 377.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml. lambdamax: 213 nm. SMILES: CCC1=CC(Cl)=C(OC)C(C(NC[C@H]2N(CC)CCC2)=O)=C1O.Cl. InChi Code: InChI=1S/C17H25ClN2O3.ClH/c1-4-11-9-13(18)16(23-3)14(15(11)21)17(22)19-10-12-7-6-8-20(12)5-2,/h9,12,21H,4-8,10H2,1-3H3,(H,19,22),1H/t12-,/m0./s1. InChi Key: HFJFXXDHVWLIKX-YDALLXLXSA-N.