Ethyl p-methoxycinnamate

Ethyl p-methoxycinnamate (EPMC) is a cinnamic acid ester that has been found in K. galanga and has diverse biological activities. It is active against T. rubrum, A. niger, S. cerevisiae, and E. floccosum when used at concentrations less than 10 µg/ml. EPMC inhibits COX-1 and COX-2 in vitro (IC50s = 1.12 and 0.83 µM, respectively). It inhibits microvessel sprouting in isolated rat aortic rings (IC50 = 91.9 µg/ml). In vivo, EPMC (60 mg/kg) reduces IL-1 and TNF-alpha production and inhibits granuloma formation in a rat model of cotton pellet-induced granuloma formation. It also increases the latency to tail withdrawal in a hot plate test in rats when administered at doses ranging from 200 to 800 mg/kg.Formal Name: 3-(4-methoxyphenyl)-2E-propenoic acid, ethyl ester. CAS Number: 24393-56-4. Synonyms: EPMC, Ethyl 4-methoxycinnamate, Ethyl para-methoxycinnamate. Molecular Formula: C12H14O3. Formula Weight: 206.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 10 mg/ml. lambdamax: 277, 310 nm. SMILES: O=C(OCC)/C=C/C1=CC=C(OC)C=C1. InChi Code: InChI=1S/C12H14O3/c1-3-15-12(13)9-6-10-4-7-11(14-2)8-5-10/h4-9H,3H2,1-2H3/b9-6+. InChi Key: DHNGCHLFKUPGPX-RMKNXTFCSA-N. Origin: Plant/Hedychium spicatum.