Ethacrynic acid
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the... more
Product information "Ethacrynic acid"
Description: Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase and Wnt signalling, producing cytotoxicity in chronic lymphocytic leukaemia cells and other tumour cells. Target: GST, Calcium Channel, Others, NF-kappaB. Smiles: CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl. References: Kunugi Y, et al. Ethacrynic acid-sensitive and ATP-dependent Cl- transport in the rat kidney[J]. Japanese Journal of Pharmacology, 1991, 57(2):167-74.
| Keywords: | Etacrynic Acid, Hydromedin, Edecrin |
| Supplier: | TargetMol |
| Supplier-Nr: | T4564 |
Properties
| Application: | Targets solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1, NKCC2) |
| MW: | 303.14 D |
| Formula: | C13H12Cl2O4 |
Database Information
| CAS : | 58-54-8| Matching products |
| KEGG ID : | K10951 | Matching products |
| Protein Atlas Nr. : | Neuropharmacologics/Ion Channel Modulators |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H312, H315, H319, H332, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P361+P364, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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