Escitalopram

Escitalopram is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and the (S) isomer of citalopram (Cay-14572) and (R)-citalopram. It selectively binds to SERT (Ki = 0.89 nM) over the norepinephrine and dopamine transporters (Kis = >10,000 and 8,150 nM, respectively) and inhibits 5-HT reuptake in rat brain synaptosomes (IC50 = 2.1 nM). Escitalopram reduces immobility in the forced swim test in mice (ED50 = 12 mg/kg), indicating anti-depressant-like activity, and increases exploratory behavior in the black-and-white box test in mice with a minimal effective dose (MED) of 0.49 mg/kg, indicating anxiolytic-like activity. Escitalopram (20 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide (Cay-10681). Formulations containing escitalopram have been used in the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD).Formal Name: (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile. CAS Number: 128196-01-0. Synonyms: (S)-Citalopram. Molecular Formula: C20H21FN2O. Formula Weight: 324.4. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 25 mg/ml, DMSO: 33 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 20 mg/ml. lambdamax: 241 nm. SMILES: CN(C)CCC[C@@]1(C2=CC=C(F)C=C2)OCC3=CC(C#N)=CC=C31. InChi Code: InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3/t20-/m0/s1. InChi Key: WSEQXVZVJXJVFP-FQEVSTJZSA-N.