Epothilone A

Epothilone A (Epo A) is a biologically active macrolide produced from the fermentation of the soil bacteria S. cellulosum that was discovered as a potent antimicrotubule agent. In competition assays, epo A binds to beta-tubulin with a similar order of magnitude as the binding of paclitaxel (Cay-10461) to beta-tubulin (IC50s = 2.3 and 3.6 µM, respectively). Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 µM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to epothilone B (Cay-10924).Formal Name: (1S,16R)-7S,11S-dihydroxy-8,8,10R,12S-tetramethyl-3S-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione. CAS Number: 152044-53-6. Synonyms: Epo A. Molecular Formula: C26H39NO6S. Formula Weight: 493.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 15 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 211, 250 nm. SMILES: C/C([C@H](C[C@H]1[C@H](O1)CCC[C@@]2(C)[H])OC(C[C@H](O)C(C([C@@H]([C@H]2O)C)=O)(C)C)=O)=C\C3=CSC(C)=N3. InChi Code: InChI=1S/C26H39NO6S/c1-14-8-7-9-19-21(32-19)11-20(15(2)10-18-13-34-17(4)27-18)33-23(29)12-22(28)26(5,6)25(31)16(3)24(14)30/h10,13-14,16,19-22,24,28,30H,7-9,11-12H2,1-6H3/b15-10+/t14-,16+,19+,20-,21-,22-,24-/m0/s1. InChi Key: HESCAJZNRMSMJG-KKQRBIROSA-N.