Enoximone

Enoximone is a phosphodiesterase 3 (PDE3) inhibitor (IC50 = 5.9 µM). It is selective for PDE3 over PDE1, -2, and -4 (IC50s = 2,100, 2,900, and 21.1 µM, respectively). Enoximone increases the force of contraction and cAMP levels in isolated canine right ventricular trabeculae, an effect that can be reversed by carbamoylcholine (carbachol, Cay-14486). In vivo, enoximone (0.1-1 mg/kg) increases cardiac contractile force in dogs. Formulations containing enoximone have been used in the treatment of congestive heart failure.Formal Name: 1,3-dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-one. CAS Number: 77671-31-9. Synonyms: MDL 17043. Molecular Formula: C12H12N2O2S. Formula Weight: 248.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM. SMILES: CSC1=CC=C(C(C2=C(C)NC(N2)=O)=O)C=C1. InChi Code: InChI=1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16). InChi Key: ZJKNESGOIKRXQY-UHFFFAOYSA-N.