Endoxifen
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: (E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by... more
Product information "Endoxifen"
Description: (E/Z)-Endoxifen ((E/Z)-Endoxifen) is an active metabolite of tamoxifen produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment. Target: Drug Metabolite, Aromatase, Estrogen/progestogen Receptor, Estrogen Receptor/ERR, Cytochromes P450, Parasite. Smiles: CC\C(=C(\c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1. References: Wu X, et al. The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells. Cancer Res. 2009 Mar 1,69(5):1722-7.
| Keywords: | (E/Z)-N-desmethyl-4-hydroxy Tamoxifen , (E/Z)-Endoxifen |
| Supplier: | TargetMol |
| Supplier-Nr: | T4281 |
Properties
| Application: | Tamoxifen metabolite |
| MW: | 373.49 D |
| Formula: | C25H27NO2 |
Database Information
| CAS : | 110025-28-0| Matching products |
| KEGG ID : | K17712 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H361, H302+H312+H332, H413 |
| P Phrases: | P201, P202, P273, P280, P308+313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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