54 products were found matching "K17712"!

(Z)-4-hydroxy Tamoxifen is an active metabolite of the estrogen receptor (ER) modulator tamoxifen (Cay-13258). It is primarily formed from tamoxifen by the cytochrome P450 (CYP) isoforms CYP2D6 and CYP2B6. (Z)-4-hydroxy Tamoxifen (10 nM) decreases progesterone receptor (PR) mRNA expression induced by the estrogen...

(E/Z)-Endoxifen is an active metabolite of tamoxifen (Cay-13258) produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6. It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen. As the efficient conversion of tamoxifen to...

1'-hydroxy Bufuralol is a metabolite of bufuralol (Cay-17794). Bufuralol is metabolized by the cytochrome P450 isoforms 2D1 and 2D2 (CYP2D1/2), therefore, quantification of the bufuralol metabolite, 1'-hydroxy bufuralol, can be used to determine CYP2D1/2 enzyme activity in humans and rats.Formal Name:...

4-hydroxy Nebivolol is a major metabolite of nebivolol (Cay-23660). It is formed by the hydroxylation of nebivolol by the cytochrome P450 (CYP) isoform CYP2D6.Formal Name: 6-fluoro-alpha-[[[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino]methyl]-3,4-dihydro-4-hydroxy-2H-1-benzopyran-2-methanol,...

5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine (Cay-15027) and fesoterodine (Cay-23777). It is formed from tolterodine by the cytochrome P450 (CYP) isoform CYP2D6 and from fesoterodine by plasma esterases. 5-hydroxymethyl Tolterodine inhibits M1-5...

Dehydro Aripiprazole is a metabolite of the atypical antipsychotic aripiprazole (Cay-19989). It is formed from aripiprazole by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2D6.Formal Name: 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-2(1H)-quinolinone, monohydrochloride. CAS Number: 1008531-60-9. Molecular...

O-Desmethyl gefitinib is the major metabolite of gefitinib (Cay-13166) in human plasma, formed by the cytochrome P450 isoform CYP2D6. It is an active metabolite that inhibits EGFR similarly to gefitinib in subcellular assays (IC50s = 36 and 22 nM, respectively) but is less active in whole cell assays (IC50s = 760...

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize...

4'-hydroxy Tamoxifen is an estrogen receptor (ER) antagonist (IC50 = 2.4 nM for the rabbit receptor) and active metabolite of tamoxifen (Cay-13258, Cay-11629). It is formed from tamoxifen by the cytochrome P450 (CYP) isoforms CYP2D6, CYP3A4, CYP2B6, and CYP2C19. 4'-hydroxy Tamoxifen inhibits the proliferation of...

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. Cytochrome P450 2D6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids....

4'-hydroxyphenyl Carvedilol is a metabolite of carvedilol (Cay-15418) that is a more potent beta-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity. It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6. 4'-hydroxyphenyl Carvedilol inhibits the...