Enalapril-d5 (maleate)

Enalapril-d5 is intended for use as an internal standard for the quantification of enalapril (Cay-16041) by GC- or LC-MS. Enalapril is an inhibitor of angiotensin-converting enzyme (ACE, IC50 = 1.2 nM in porcine plasma). In vivo, enalapril (0.05-1 mg/kg, p.o.) inhibits pressor responses induced by angiotensin I (Cay-24737) in rats and dogs in a dose-dependent manner. Enalapril reduces heart rate, systolic and diastolic blood pressures, and heart weight/body weight ratio in salt-sensitive and -resistant Dahl rats fed a high-salt or low-salt diet. Formulations containing enalapril have been used for the treatment of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.Formal Name: N-[1-(ethoxycarbonyl)-3-(phenyl-d5)propyl]-L-alanyl-L-proline, 2Z-butenedioate. CAS Number: 349554-02-5. Molecular Formula: C20H23D5N2O5 . C4H4O4. Formula Weight: 497.6. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: Ethanol: Soluble, Methanol: Soluble, Water: Soluble. SMILES: O=C(OCC)[C@@H](N[C@@H](C)C(N1CCC[C@H]1C(O)=O)=O)CCC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H].OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C20H28N2O5.C4H4O4/c1-3-27-20(26)16(12-11-15-8-5-4-6-9-15)21-14(2)18(23)22-13-7-10-17(22)19(24)25,5-3(6)1-2-4(7)8/h4-6,8-9,14,16-17,21H,3,7,10-13H2,1-2H3,(H,24,25),1-2H,(H,5,6)(H,7,8)/b,2-1-/t14-,16-,17?,/m0./s1/i4D,5D,6D,8D,9D,. InChi Key: OYFJQPXVCSSHAI-ZQITZENZSA-N.