Emraclidine
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An M4 muscarinic receptor PAM, selective for M4 mAChRs over a panel of 59 receptors, ion... more
Product information "Emraclidine"
An M4 muscarinic receptor PAM, selective for M4 mAChRs over a panel of 59 receptors, ion channels, transporters, and enzymes at 10 µM, selectively potentiates ACh-induced activation of the M4 mAChR over M1-M3 and M5 mAChRs in cells expressing the human receptors (EC50s = 12.3, 4,798, >10,000, >10,000, and >10,000 nM, respectively), inhibits amphetamine-induced locomotor activity in mice and prepulse inhibition deficits in rats at 3.2 mg/kg. Formulation: A solid. InChI: InChI=1S/C20H21F3N4O/c1-12-5-13(2)25-17-11-27(10-16(12)17)19(28)6-14-8-26(9-14)15-3-4-24-18(7-15)20(21,22)23/h3-5,7,14H,6,8-11H2,1-2H3. InChIKey: DTCZNKWBDTXEBS-UHFFFAOYSA-N. SMILES: O=C(CC1CN(C1)C2=CC(C(F)(F)F)=NC=C2)N3CC4=NC(C)=CC(C)=C4C3
| Keywords: | CVL-231, PF-06852231, 1-(5,7-dihydro-2,4-dimethyl-6H-pyrrolo[3,4-b]pyridin-6-yl)-2-[1-[2-(trifluoromethyl)-4-pyridinyl]-3-azetidinyl]-ethanone |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 42125 |
Properties
| Application: | M4 muscarinic receptor positive allosteric modulator (PAM) |
| Immunogen: | 390.4 |
| MW: | 390.4 D |
| Formula: | C20H21F3N4O |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 2170722-84-4| Matching products |
| KEGG ID : | K04132 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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