EML4-ALK Kinase Inhibitor 1

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Item number	Size	Manual	Delivery time	Price
Cay45387-1	1 mg	-	6 - 10 business days*	133.00€
Cay45387-5	5 mg	-	6 - 10 business days*	495.00€
Cay45387-10	10 mg	-	6 - 10 business days*	727.00€

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EML4-ALK kinase inhibitor 1 is an inhibitor of the anaplastic lymphoma kinase (ALK) fusion... more

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Product information "EML4-ALK Kinase Inhibitor 1"

EML4-ALK kinase inhibitor 1 is an inhibitor of the anaplastic lymphoma kinase (ALK) fusion protein EML4-ALK (IC50 = 1 nM). It inhibits the growth of Ba/F3 cells expressing EML4-ALK (IC50 = 9.7 nM). In vivo, EML4-ALK kinase inhibitor 1 (10 mg/kg) induces tumor regression in mice xenografted with NIH3T3 cells expressing EML4-ALK.. SMILES: CN1CCN(C2CCN(C(C=CC(NC3=NC(N[C@@H]4CC[C@H](CC4)OC)=C(N=C3C(N)=O)CC)=C5)=C5OC)CC2)CC1. InChi Code: InChI=1S/C31H48N8O3/c1-5-25-30(33-21-6-9-24(41-3)10-7-21)36-31(28(35-25)29(32)40)34-22-8-11-26(27(20-22)42-4)39-14-12-23(13-15-39)38-18-16-37(2)17-19-38/h8,11,20-21,23-24H,5-7,9-10,12-19H2,1-4H3,(H2,32,40)(H2,33,34,36)/t21-,24-. InChi Key: KBHZCRDGGWIHQF-SAIGFBBZSA-N

Keywords:	6-ethyl-5-[(trans-4-methoxycyclohexyl)amino]-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-2-pyrazinecarboxamide
Supplier:	Cayman Chemical
Supplier-Nr:	45387

Properties

Application:	EML4-ALK inhibitor
MW:	580.78 D
Formula:	C31H48N8O3
Purity:	>95%
Format:	Solid

Database Information

CAS :	1373409-08-5\| Matching products
KEGG ID :	K05119 \| Matching products

Handling & Safety

Storage:	-20°C
Shipping:	-20°C (International: -20°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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