EMA401

EMA401 is an orally bioavailable and selective antagonist of the angiotensin II type 2 receptor (AT2, IC50s = 39.5 and 408,000 nM for rat recombinant AT2 and AT1, respectively). It inhibits capsaicin-induced calcium influx in cultured human dorsal root ganglion (hDRG) neurons (IC50 = 10 nM) and reduces neurite density and length in rat DRG neuronal cultures. EMA401 has analgesic effects in a rat model of neuropathic pain induced by chronic constriction injury.Formal Name: (3S)-2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid. CAS Number: 1316755-16-4. Molecular Formula: C32H29NO5. Formula Weight: 507.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 0.1 mg/ml. SMILES: O=C(N1[C@H](C(O)=O)CC(C(OCC2=CC=CC=C2)=C(OC)C=C3)=C3C1)C(C4=CC=CC=C4)C5=CC=CC=C5. InChi Code: InChI=1S/C32H29NO5/c1-37-28-18-17-25-20-33(31(34)29(23-13-7-3-8-14-23)24-15-9-4-10-16-24)27(32(35)36)19-26(25)30(28)38-21-22-11-5-2-6-12-22/h2-18,27,29H,19-21H2,1H3,(H,35,36)/t27-/m0/s1. InChi Key: GHBCIXGRCZIPNQ-MHZLTWQESA-N.