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Item number: Cay22988-1

EMA401 is an orally bioavailable and selective antagonist of the angiotensin II type 2 receptor (AT2, IC50s = 39.5 and 408,000 nM for rat recombinant AT2 and AT1, respectively). It inhibits capsaicin-induced calcium influx in cultured human dorsal root ganglion (hDRG) neurons (IC50 = 10 nM) and reduces neurite...

Keywords:	(3S)-2-(2,2-diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-(phenylmethoxy)-3-isoquinolinecarboxylic acid
Application:	Angiotensin II type 2 receptor antagonist
CAS	1316755-16-4
MW:	507.6 D

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Olodanrigan

Item number: TGM-T4431-100mg

Description: Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. EMA401 blocks p38, p42/p44 mitogen-activated protein kinase (MAPK) activation, neurite...

Keywords:	PD-126055 , EMA401
Application:	Angiotensin II type 2 receptor antagonist
CAS	1316755-16-4
MW:	507.58 D

From 34.00€ *

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