Eliprodil

N-Methyl-D-aspartate (NMDA) receptors are calcium permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. Eliprodil is a non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents. It is selective for NR2B subunit-containing receptors (IC50 = 1 µM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C subunits. Eliprodil also avidly binds sigma1 and sigma2 sites (Kis = 0.013 and 0.63 µM, respectively). It is effective in vivo, blocking ischemia-induced neurodegeneration in the CA1 region of the hippocampus of gerbils subjected to bilateral carotid artery occlusion. Eliprodil can also have proarrhythmic actions in hearts under normal conditions.Formal Name: alpha-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol. CAS Number: 119431-25-3. Synonyms: SL 820715. Molecular Formula: C20H23ClFNO. Formula Weight: 347.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10mg/mL, DMSO: 2mg/mL, Ethanol: 2mg/mL. lambdamax: 216, 266, 272 nm. SMILES: FC1=CC=C(CC2CCN(CC(O)C3=CC=C(Cl)C=C3)CC2)C=C1. InChi Code: InChI=1S/C20H23ClFNO/c21-18-5-3-17(4-6-18)20(24)14-23-11-9-16(10-12-23)13-15-1-7-19(22)8-2-15/h1-8,16,20,24H,9-14H2. InChi Key: GGUSQTSTQSHJAH-UHFFFAOYSA-N.