Dyngo-4a

Dyngo-4a is an inhibitor of dynamin with IC50 values of 380 and 2,300 nM for native sheep brain dynamin 1 and recombinant rat dynamin 2, respectively. It inhibits dynamin 1 helix formation induced by L-phosphatidylserine (PS) liposomes (IC50 = 0.38 µM) more potently than dynamin 1 single-ring formation induced by Grb2 (IC50 = 39.2 µM) and does not inhibit the basal GTPase activity of dynamin. Dyngo-4a inhibits non-neuronal clathrin-mediated (IC50 = 5.7 µM in U2OS cells) and synaptic vesicle endocytosis (IC50 = 26.8 µM in rat brain synaptosomes).Formal Name: 3-hydroxy-2-naphthalenecarboxylic acid, 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide. CAS Number: 1256493-34-1. Molecular Formula: C18H14N2O5. Formula Weight: 338.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 223, 290, 367 nm. SMILES: OC1=CC2=C(C=CC=C2)C=C1C(N/N=C/C3=CC(O)=C(O)C=C3O)=O. InChi Code: InChI=1S/C18H14N2O5/c21-14-8-17(24)16(23)7-12(14)9-19-20-18(25)13-5-10-3-1-2-4-11(10)6-15(13)22/h1-9,21-24H,(H,20,25)/b19-9+. InChi Key: UAXHPUSKEWEOAP-DJKKODMXSA-N.