Dynarrestin

Dynarrestin is an inhibitor of dynein 1 and -2. It inhibits dynein 1-dependent microtubule gliding (IC50 = 5 µM) and dynein 2-dependent intraflagellar transport in mIMCD-3 inner medullary collecting duct cells when used at concentrations of 0.125 and 1.25 µM. Dynarrestin decreases the number of cells in metaphase, anaphase, or telophase in asynchronous COS-7 cells (IC50 = 6.25 µM). It inhibits the proliferation of primary Ptch+/- murine medulloblastoma cells (IC50 = 0.068 µM) and the expression of GLI1 in KYSE-180 esophageal squamous cell carcinoma cells stimulated with the smoothened (Smo) agonist purmorphamine (Cay-10009634, IC50 = 0.21 µM).Formal Name: 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-5-thiazolecarboxylic acid, ethyl ester. CAS Number: 2222768-84-3. Molecular Formula: C22H23F2N3O2S. Formula Weight: 431.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMSO: 14 mg/ml, Ethanol: Slightly soluble, PBS (pH 7.2): 0.30 mg/ml. lambdamax: 236, 281, 324, 367 nm. SMILES: O=C(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(NC3=C(F)C=C(F)C=C3)S1)OCC. InChi Code: InChI=1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26). InChi Key: UZNNDDDSGCMQOQ-UHFFFAOYSA-N.