DuP-697

DuP-697
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay70645-5 5 mg -

6 - 10 business days*

112.00€
Cay70645-10 10 mg -

6 - 10 business days*

178.00€
Cay70645-25 25 mg -

6 - 10 business days*

418.00€
Cay70645-50 50 mg -

6 - 10 business days*

779.00€
 
DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes... more
Product information "DuP-697"
DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1. The IC50 values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively. The IC50 for the inhibition of human recombinant COX-1 after the same time intervals is 9 µM. DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin. Formal Name: 5-bromo-2-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-thiophene. CAS Number: 88149-94-4. Molecular Formula: C17H12BrFO2S2. Formula Weight: 411.3. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 54 mg/ml, DMSO: 15 mg/ml, Ethanol: 7 mg/ml, PBS:DMF (1:1): 0.5 mg/ml. lambdamax: 254, 300 nm. SMILES: Fc1ccc(cc1)c1sc(Br)cc1c1ccc(cc1)S(=O)(=O)C. InChi Code: InChI=1S/C17H12BrFO2S2/c1-23(20,21)14-8-4-11(5-9-14)15-10-16(18)22-17(15)12-2-6-13(19)7-3-12/h2-10H,1H3. InChi Key: AJFTZWGGHJXZOB-UHFFFAOYSA-N.
Keywords: 5-bromo-2-(4-fluorophenyl)-3-(4-(methylsulfonyl)phenyl)-thiophene
Supplier: Cayman Chemical
Supplier-Nr: 70645

Properties

Application: COX-2 inhibitor
MW: 411.3 D
Formula: C17H12BrFO2S2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 88149-94-4| Find alternatives
KEGG ID : K11987 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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