DPPI 1c (hydrochloride)

DPPI 1c is an inhibitor of dipeptidyl peptidase 4 (DPP-4, IC50 = 104 nM in an enzyme assay). It decreases plasma glucose levels by 46 to 67% in an oral glucose challenge in fasted, diabetic KK/H1J mice when administered at doses ranging from 0.3 to 5 mg/kg. DPPI 1c decreases plasma DPP-4 activity by approximately 50% and increases plasma glucagon-like peptide 1 (GLP-1) levels in KK/H1J mice.Formal Name: (2R,5S)-rel-1-[2-[[1-(hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-pyrrolidinedicarbonitrile, monohydrochloride. CAS Number: 866396-70-5. Molecular Formula: C14H20N4O2 . HCl. Formula Weight: 312.8. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 25 mM, Water: 50 mM. SMILES: O=C(CNC1(CO)CCCC1)N2[C@@H](C#N)CC[C@H]2C#N.Cl. InChi Code: InChI=1S/C14H20N4O2.ClH/c15-7-11-3-4-12(8-16)18(11)13(20)9-17-14(10-19)5-1-2-6-14,/h11-12,17,19H,1-6,9-10H2,1H/t11-,12+,. InChi Key: RHCWAHDCHQTNBR-IWKKHLOMSA-N.