DKM 2-93

DKM 2-93 is a cysteine-reactive covalent inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5, IC50 = 450 µM). It decreases survival of PaCa-2 pancreatic cancer cells without affecting human pancreatic ductal epithelial cells (HPDEs) when used at a concentration of 50 µM. In vivo, DKM 2-93 (50 mg/kg per day) reduces tumor volume without reducing body weight in a PaCa-2 pancreatic cancer mouse xenograft model. It has also been used as an intermediate in the synthesis of topoisomerase I inhibitors and compounds active against M. tuberculosis.Formal Name: 2-chloro-N-[(3,4-dimethoxyphenyl)methyl]-acetamide. CAS Number: 65836-72-8. Molecular Formula: C11H14ClNO3. Formula Weight: 243.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: Soluble, Methanol: Soluble. lambdamax: 230 nm. SMILES: O=C(CCl)NCC1=CC=C(C(OC)=C1)OC. InChi Code: InChI=1S/C11H14ClNO3/c1-15-9-4-3-8(5-10(9)16-2)7-13-11(14)6-12/h3-5H,6-7H2,1-2H3,(H,13,14). InChi Key: CETPWRGZGWGPSV-UHFFFAOYSA-N.