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DKM 2-93
Item number: Cay37293-100
DKM 2-93 is a cysteine-reactive covalent inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5, IC50 = 450 µM). It decreases survival of PaCa-2 pancreatic cancer cells without affecting human pancreatic ductal epithelial cells (HPDEs) when used at a concentration of 50 µM. In vivo, DKM 2-93 (50 mg/kg per...
| Keywords: | 2-chloro-N-[(3,4-dimethoxyphenyl)methyl]-acetamide |
| Application: | UBA5 covalent inhibitor |
| CAS | 65836-72-8 |
| MW: | 243.7 D |
From 42.00€
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DKM 2-93
Item number: TGM-T7415-1mL
Description: DKM 2-93 is a relatively selective inhibitor of UBA5 (IC50: 430 µM). Target: E1/E2/E3 Enzyme. Smiles: COC1=C(OC)C=C(CNC(=O)CCl)C=C1. References: Roberts A M , Miyamoto D K , Huffman T R , et al. Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target[J]. ACS...
| Application: | UBA5 covalent inhibitor |
| CAS | 65836-72-8 |
| MW: | 243.69 D |
30.00€
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